The anime is based on the manga.
Overall, because of the theme of this anime, it is pretty serious. It is good and a nice anime if you watch it like one episode a day, but if you are like me, watching like several episodes back to back, (on this issue, i do not blame me, i blame the fansub groups, anime-kraze and anime-keep) for releasing 4 or 5 episodes at once in a short period of time. The story gets somewhat gruesome and dark, it is actually i would say suited more for a TV documentary than for an anime.
Theres little humor in all the episodes i have seen, maybe when you see like surprise murderers, it is not going to be very fun. Also the story is presented in the way in which it kind of drags. some episodes are not very much needed.

Before I proceed, know that I prefer my anime on the dramatic, realistic side. With that in mind...<p />
As far as presentation goes, I will say this: for an anime, the premise is fairly unique. Set in Europe with a largely European cast, no giant robots or enormous swords flying around, no karaoke...well, no, there is one scene with karaoke but it's not in the usual fashion. The hero, Dr. Tenma, although extraordinarily talented is really just an ordinary guy. You get the impression it could happen to anyone. You get the impression that if it was a German doctor and not a Japanese doctor, things could turn out similarly. Girls don't fall in love with him at the drop of a hat, and there are no hot springs. This is a drama coupled with a bit of whodunnit and suspense.